A stress adaptation pathway termed here the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa).Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in vitro and in vivo, and is active in PCa patient sa
The brine shrimp Artemia is a micro-crustacean, well adapted to the harsh conditions that severely hypersaline environments impose on survival click here and reproduction.Adaptation to these conditions has taken place at different functional levels or domains, from the individual (molecular-cellular-physiological) to the population level.Such condi
Objective: This research was done to identify the effects of dry cupping therapy on the shoulder pain and fatigue of nurses.Methods: The research design was time series design.The participants were 27 nurses moondrop quarks with shoulder pain at P University Hospital in Busan metropolitan city from July 6, 2009 to August 3, 2009.The dry cupping the
By ratifying the Sendai Framework for Disaster Risk Reduction (SFDRR), the Australian Government has accepted the need to mainstream disaster risk reduction (DRR) principles into policy and procedures.This research explores the extent to which this rhetoric has been actioned, using local-government policy as an indicator.The rationale for this appr
Intellect is a tool of thought contained in human beings, the human mind is different from other creatures because sense is given only in humans and is not given to other creatures.This difference has made humans superior and smarter in managing lovesense 3 their lives.Therefore man with a clear intellect would find God as the final returns from re